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Symbol
Name
ID

Spast
spastin
MGI:1858896

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Ankle clonus

Spasticity

Lower limb spasticity

Spastic paraplegia

Spastic gait

Degeneration of the lateral corticospinal tracts

Ataxia

Babinski sign

Paraplegia

Dysarthria

Depression

Apathy

Aggressive behavior

Disinhibition

Agitation

Cognitive impairment

Memory impairment

Dementia

Intellectual disability

Hyperreflexia

Brisk reflexes

Hyperreflexia in upper limbs

Seizure

Impaired vibration sensation at ankles

Impaired vibration sensation in the lower limbs

Disease(s) Associated with SPAST

hereditary spastic paraplegia 4

Mouse Phenotypes		abnormal brain morphology	hydrocephaly	abnormal axon morphology	abnormal axonal transport
Availability	Mouse Genotype	abnormal brain morphology	hydrocephaly	abnormal axon morphology	abnormal axonal transport
	Spast^M1Gri/Spast^M1Gri
	Spast^tm1.1Evre/Spast^tm1.1Evre
	Spast^tm1.1Jme/Spast^tm1.1Jme
	Spast^{tm1b(KOMP)Wtsi}/Spast^{tm1b(KOMP)Wtsi}
	Spast^M1Gri/Spast⁺
	Spast^tm1.1Jme/Spast⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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